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Laboratory Tests

DNA parental testing uses DNA characteristics to determine whether two individuals, in this case father/mother and child are biologically related. Tests can also determine the likelihood of someone being a biological grandparent. The individual pattern of short tandem repeats (STRs) also known as microsatellites result from a combination of the unique alleles differ between persons, with the exception of monozygotic twins. Parents transmit one of their two alleles to their offspring which allows for the confirmation or exclusion paternity by comparing the microsatellite (MS) pattern between child and parents. Nowadays very reliable kinship analyses can be performed by means of molecular genetic methods.

Laboratory testing:  DNA is isolated from the test material (blood or buccal swabs) and then the so-called “short tandem repeats” (STRs) are amplified using microsatellite (MS) analysis via PCR. STRs or MSs are short or variable length sequences located in non-coding parts of the entire genome on an individual. The pattern of the different STRs is unique for every person (except for monozygotic twins) and is referred to as the genetic fingerprint. At least 16 different STR systems are routinely examined.

Depending on the frequency of the detected alleles, there is, as a rule, a probability of paternity of 99.9% achieved (paternity practically proven). Exclusion from paternity occurs if there are at least four paternal alleles in the child, those in the putative father cannot be proven. The investigations are limited to the analysis of DNA characteristics that - with the exception of gender- do not allow any direct conclusions to be drawn about personal characteristics, and only the clarification to serve the questionable parentage or relationship.

Source: https://humane-genetik.de/en/diagnostics/kinship-analysis/

There are other advanced tests available upon your doctor’s request. Contact us on 059 691 1883, 050 168 2733 for further details or booking.

Sexual Health

Many people with sexually transmitted infections (STIs) do not get symptoms, so it is worth getting tested periodically if you are sexually active or having unprotected sex. We treat all our patients with the highest level of confidentiality irrespectively of the test you do.

Male/ Female

  • Syphilis Screen
  • HIV Screen
  • Chlamydia
  • Gonorrhea

There are other advanced tests available upon your doctor’s request. Contact us on 059 691 1883 for further details or booking.

Allergy Screen

Allergic reactions are triggered when allergens interact with already formed antibodies (IgE) bound to certain receptors on specific mast cells. The extent of reaction is dependent on the amount of antigen or allergen as well as the mode of entry into the human system. Once activated, the specific antibody (IgE) induces an inflammatory reaction by releasing chemical mediators and synthesizing leukotrienes and cytokines. Signs and symptoms of allergic reactions range from the irritating sniffles of hay fever when pollen is inhaled, to the life-threatening circulatory collapse that occurs in systemic anaphylaxis also known as anaphylactic shock when some individuals ingest peanuts.

Laboratory Testing: When an individual is suspected of having an allergy, a specific IgE test is requested to help confirm or rule out the suspicion of the allergy. IgE antibody developments can be detected at an early stage, in which case, indicating sensitization, even before clinical signs and symptoms have developed.

In determining allergic reactions to specific substances, (ie, certain specific food items), radioimmunoassay test (RAST) is used to determine the extent of reaction when the individuals blood sample comes into contact with the requested allergen.

Results of testing are categorized in CAP-classes (1-6) and show a good link between the presence of IgE antibody in serum, positive skin or provocation tests (if tested), as well as symptoms of allergy. Positive CAP results to a specific allergen demonstrate specific IgE sensitization but are not proof that the allergen is the cause of clinical symptoms.

As in all diagnostic testing, a definitive clinical diagnosis should not be based solely on the results of a single laboratory test method. However, a diagnosis should be made by the physician after evaluation of all clinical and laboratory findings.

Below are a series of tests that can be selected individually;

  • Inhalation allergen screen
  • Food allergen screen
  • Total IgE
  • Eczema
  • Gastro adult
  • Asthma/ Rhinitis perennial
  • Gastro childs
  • Asthma/ Rhinitis

Source: Synlab Parameters Index, Synlab MVZ Leinfelden, 2016/2017 edition. Version 1.0/1617

There are other advanced tests available upon your doctor’s request. Contact us on 059 691 1883 for further details or booking.

Attachments:
File
Download this file (synlab_allergy_request.pdf)Download Request Form

Heart Health

It is said that over a person’s average lifetime, their heart beats about 2.5 billion times. This obviously tells us how important the heart is and impresses on us the need to take good care of it. There are several tests that can help determine the health of our heart.

  • Cardiac Enzymes
  • Pro BNP
  • Lipid Profile
  • Chest X-ray
  • Echocardiogram (ECHO)
  • D-Dimer
  • Troponin T
  • Troponin I

There are other advanced tests available upon your doctor’s request. Contact us on 059 691 1883 for further details or booking.

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